If you're chemically sensitive, it's probably not a good idea to get it installed, but it's also not a good idea to breathe musty air from the crawl space either. In addition, your house and its contents are made of lots of materials that affect your indoor air quality. If you're really concerned about this, hire a company to test your air and tell you what you can do about it.
Spray Foam Sealant
Allison--would be very interested in your take on the GHG issues of foams, which have received lots of smart commentary recently. To highlight a few: architect Jesse Thompson's comments on Tom's Good vs Bad post on Energy Circle, the very thorough piece by Alex Wilson on Green Building Advisor and Michael Anschel's cautionary diatribe on Remodeling.
I had a hole in the drywall in our bathroom that was about 2 in x 5 in that I used Great Stuff to fix. I am impressed with the characteristics of the filler. It filled the hole completely in a few seconds of application. I will warn anyone using it though to make sure you don't fill the hole entirely flush to the wall because this stuff continues expanding after you apply it. I didn't think about that but no big deal really because you can sand it which is exactly what I did, and then applied spacial and paint and it is almost as good as new. For the price this was a heck of a deal because I only used a tiny amount and now am left with nearly a full can. I guess I will have to find somewhere else to use it now. Great product, ... full review
Spray Foam On Roof Deck
For large jobs, professionals such as Dr. Energy Saver use two-part foam, which comes in larger containers. With 2-part spray foam, it's necessary to mix separate resin and catalyst compounds at the application nozzle. Combining these ingredients starts a chemical reaction that creates expanding foam. Contractors use small 2-part foam "kits" to air-seal an attic or to seal and insulate ductwork. To insulate an entire attic or wood-framed wall with spray foam, the resin and catalyst compounds are pumped to the application nozzle from 50-gallon drums in a specially equipped truck.
When choosing a waterproofing and sealing product, we must see to it that we can easily use and apply it using simple tools, including a squeegee or a paint roller. With ease of application, we can be certain that we can achieve hassle-free application and smoother and more attractive finish than other products could give. So when reviewing the products we have featured above, we have made sure that they are easy to apply.